Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors.
نویسندگان
چکیده
We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 17 شماره
صفحات -
تاریخ انتشار 2012